Experiment Copilot
Automate your synthesis experiments
Chemical synthesis automation platform. By flexibly connecting the thermometer, pH probe, stirrer, temperature control unit(TCU), and liquid dosing unit to the control unit, chemists can easily set up experimental orders on the touch screen, so that the synthesis work can be performed automatically 24/7, and the data is 100% captured, ensuring that the chemical reaction is highly reproducible. Make experiments more efficient, accurate, and safer.
Features
· Flexible Equipment Setting
ECP100 is designed for plug-and-play operation and facilitates quick connection to different kinds of thermometers, pH probes, stirrers, TCU and liquid dosing unit, etc.
· Precise Control
Critical parameters such as rotation speed (±1%), temperature (±0.5°C), pH (±0.05), liquid droplet dosage (Min=50μL), and drip rate (0-6mL/min) can be accurately controlled to support the reproduction of complex reaction conditions.
· 24/7 Unattended Execution
Experiments can be executed automatically 24/7 according to the process recipe.
· 100% Real-time Data Captured
Continuously collect and save real-time data from all the sensors and equipment.
· Intelligent Gradient Temperature Control
It can realize the precise gradient temperature control of the high and low temperature all-in-one machine, and can customize the target temperature and duration in segments to ensure that the reaction temperature rises and falls at a uniform rate, accurately matches the theoretical model, and improves the purity of the product and the synthesis efficiency.
Constructions
· Control Unit
· Liquid Dosing Unit
· Glass Digital Thermometer
· Stainless Steel Thermometer
· pH probe
· Stirrer
· Temperature Control Unit(TCU)
· Jacketed Lab Reactor
Note：Equipment can be freely combined based on experimental needs.
Specifications
· Dimensions: 320mm * 260mm * 110mm
· Weight: 3.7 kg
· Enclosure material: SUS304 with PTFE coating
· Accessories & interfaces
Thermometer * 2
pH probe * 1
Liquid dosing unit * 1
TCU * 1
Magnetic/mechanical stirrer * 1
Stylus pen * 1
RJ45 port * 2
Thermometer * 2
pH probe * 1
Liquid dosing unit * 1
TCU * 1
Magnetic/mechanical stirrer * 1
Stylus pen * 1
RJ45 port * 2
· User interface: 7-inch touchscreen display
Customer Case
Intelligent Gradient Temperature Control Empowers Crystal Polymorph Control
Background
A drug R&D team, aiming to stably prepare the high - bioavailability Form I crystal of an API, faces multiple challenges. The compound has different crystal form and the process control is complex (involving temperature gradient control, stirring adjustment, and antisolvent addition) . Key issues include:
· Heavy manual workload: Monitoring multiple - stage cooling for over 12 hours, with experiments lasting over 18 hours in total.
· Process control difficulty: Needing precise coordination between antisolvent addition speed and internal temperature, as manual operation is prone to errors.
· Poor repeatability: Significant parameter fluctuations, incomplete data recording, and difficulty tracing critical factors.
· Large execution deviations: Inconsistencies between design parameters and actual operations, affecting crystal form control.
Solutions
Introducing the ECP100 for process development:
· Comprehensive Parameter Programming：Input parameters such as temperature and drip timing, and the system automatically executes multiple parameter interactions.
· Full Process Data Recording: Real-time monitoring of critical parameters including temperature, drip volume, and drip speed, supporting rapid deviation detection.
· Solvent Addition Interlock: A high-precision intelligent liquid dispensing module (accuracy ±1%) dynamically adjusts drip speed and temperature.
· Intelligent Gradient Temperature Control: Predefined multi-gradient cooling strategies (stepwise/linear) automatically execute temperature control without the need for supervision.
Outcomes
· Enhanced Efficiency: Automation replaces human monitoring, resulting in a 100% increase in efficiency and resolving shift work issues.
· Success Rate Improvement: The success rate of Form I preparation has increased from 40% to 95%.
· Breakthrough in Reproducibility: Comprehensive parameter programming control ensures 100% recording of all process data, significantly enhancing experimental reproducibility.
· Accelerated Development: Data-driven approaches rapidly identify critical parameters (such as cooling rate), reducing the development cycle by 50%.
· Optimized Management: The transparency and standardization of the experimental process enhance team collaboration efficiency.
