Liquid Preparation (Dissolution Media)
Precisely prepare 96L of dissolution media per hour
This is a fully automated dissolution medium preparation system. It uses intelligent calculations and multi-channel precise fluid control technology to allow for the one-click preparation of dissolution media with any desired pH value (such as phosphate buffer and acetate buffer). With a maximum flow rate of 1.6L/min, it achieves an accuracy comparable to manual titration while significantly outperforming traditional methods in speed.
The system features a patented design that enables the continuous switching between different types of media without the need to clean the pipelines, eliminating the time-consuming cleaning processes typical of conventional systems. Additionally, it is compliant with GMP (Good Manufacturing Practice) standards, with the preparation process thoroughly recorded for easy deviation analysis and quality traceability.
Aligned with dissolution research standards, this system can quickly fulfill the needs for preparing dissolution media at various pH levels in drug development. It also supports expansion with modules for degassing, heating, and precise liquid dispensing, making it suitable for a wide range of applications in both research and pharmaceutical settings.
Features
· Ultra-fast Preparation
Achieves a maximum preparation speed of 1.6 L/min, allowing for the precise formulation of 96L of standard dissolution media per hour, increasing efficiency by over five times compared to manual methods.
· One-click Preparation
Features a built-in pharmacopoeia-grade formula database. Simply select a formula and input the desired volume to automatically prepare the media, requiring no manual intervention.
· Intelligent Calculation and Control
The system incorporates a real-time concentration deconstruction model, precisely controlling the multi-channel pump and valve interactions with an accuracy of ±1%.
· Zero Residue Switching
This innovative patented design allows for switching between different media without the need to clean the pipelines, preventing residue and cross-contamination.
· Comprehensive Medium Coverage
Supports a wide range of common dissolution media that meet USP/EP/ChP/JP pharmacopoeia standards, including phosphate, acetate, and hydrochloric acid buffers, with options for custom formulations.
· Modular Expansion
Can be connected to additional modules for online degassing, heating, and precise liquid dispensing, accommodating complex application scenarios.
· Full Data Traceability
Logs for login, preparation, calibration, and material status can be recorded, with options for USB/RJ45 export or direct printing, supporting compliance with GMP environments.
· Cost Savings
30~60% cost saving per batch of dissolution media.
· Comply with GMP Requirements
The equipment and software passed pharma quality systems, which could be applied both in R&D lab and QC lab.
Specifications
· Dimensions: 486mm*610mm*494mm
· Weight: 45kg
· Dissolution medium: Phosphoric buffer, acetic buffer, hydrochloric acid etc.
· Preparation speed: 1.6L/min
· Accuracy: ±1%
· Minimal Preparation volume per time: 1L
· Access control: Administrator, Maintainer, Operator
· Log book: Replace manual records with a printing module to ensure that complete data in the preparation process can be tracked.
Customer Case
One-click preparation of acetate dissolution medium—reducing manual preparation time from 30 minutes to just 5 minutes.
Background
A drug research laboratory needs to prepare 20 batches of acetate buffer (pH 4.5 ± 0.05) daily for dissolution testing. The manual process requires frequent calibrations, with pH adjustments taking up to 10 minutes per batch, resulting in researchers dedicating significant time to low-value repetitive tasks.
Solution
Introducing the LP100 for liquid preparation automation:
· Intelligent calculation and control: By utilizing the built-in formula for pH 4.5 acetate buffer according to Chinese pharmacopoeia standards, operators simply input the desired volume. The system automatically calculates the ratio of concentrated acetic acid to pure water, coordinating multi-channel dispensing to directly produce a medium with a pH of 4.50 ± 0.05, eliminating the need for adjustments.
· Preparation process recorded: A printed log of the preparation process can be generated, which can be attached to the experimental record book.
Outcomes
· The time required for preparing each batch has been reduced from 30 minutes to just 5 minutes, minimizing repetitive labor and enhancing research efficiency.
· Human error has been significantly reduced, leading to overall cost savings of 30%-60%.
· The fully enclosed piping system effectively prevents the spread of odors, thereby lowering occupational health risks for laboratory personnel.
Reliability Test
Equipment Reliability
The high-precision liquid volume control technology enables continuous operation under extreme workload conditions, having successfully completed a 30,000L continuous liquid dispensing test. The solution preparation error is consistently maintained within ±1%, ensuring reliable data integrity for dissolution testing.
Concentrated Solution Reliability
Test substances were stored under controlled temperature conditions of 20°C ±2°C to evaluate stability over a 6-month period. Samples collected at 0, 1, 2, 3, and 6 months demonstrated test results that fully complied with standard specifications.
